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KMID : 1094020170340060404
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Journal of Veterinary Clinics
2017 Volume.34 No. 6 p.404 ~ p.409
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Hepatoprotective Effect of Blue Honeysuckle on Rat Hypothyroidism
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Lee Woo-Yeol
Yi Seong-Joon
Yun Sung-Ho
Oh Tae-Ho
Kim Hong-Tae
Lim Mee-Kyung
Lee Keun-Woo
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Abstract
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This study was to determine whether blue honeysuckle lyophilized concentrated powder (BH) has positive effects on hypothyroidism and related liver damage in propylthiouracil-induced Hypothyroidism. Levothyroxine (LT4)-treated group was administrated by intraperitoneal injection with LT4, while BH or Flos Lonicerae lyophilized aqueous extract (LF)-treated groups were orally administrated for 42 days which two weeks pri or to PTU injection. The changes in organ weight, serum AST & ALT, serum lipid level, liver defense system were measured and the histopathology of the liver was observed. The oral administrations of 125, 250, and 500 mg/kg of BH showed favorable effects compared to LF on hypothyroidism-related liver damages through the enhance antioxidant defense system.
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KEYWORD
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blue honeysuckle, hypothyroidism, Levothyroxine, liver, rat
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